In 10 – 15% of pts, usually with >40% LV infarct, there is 70% mortality.
Pericarditis after an MI is typically fibrinous or fibrinohemorrhagic. Typical onset 2 – 3 days after acute MI, then resolves.
Large anterior transmural MI’s have a higher risk of rupture, expansion, aneurysm, thrombi & in general have a worse prognosis than posterior MI's.
Large posterior transmural MI’s have a higher risk of heart blocks, RV infarct (or both).
Compensatory remodeling occurs with healing of MI with compensatory hypertrophy and areas of thinning, scarring and dilatation. May get late decompensation of the myocardium.
The conventional wisdom has been that cardiac myocytes cannot regenerate and are replaced by scar tissue when they die. There is some evidence to the contrary, but myocyte regeneration, if it occurs, does not play much of a role in the healing of an MI.