Issue 2, pages 112–133, February 2009 2009, 61(2): 112–133, 2009 2B5f water

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PERSPECTIVES Since the discovery in 1985 of the first WCPS, hundreds of such proteins have been identified in organisms from all kingdoms of life. It is clear that WCPSs (and MIPs) play major roles in a broad array of basic physiological processes in all cells and organisms in which such proteins are expressed. However, future research should clearify the physiological roles of MIPs in organisms and cells where the role is not yet obvious; such is the case of some MIPs in microorganisms, of SIPs in plants, of other subcellular AQPs in animals and humans. Future work is needed to discover new members of the MIP superfamily in diverse organisms and to assign them a physiological role. An important direction of research is represented by studies leading to new methods for diagnosis and therapy of diseases in veterinary and human medicine based on progress in understanding the precise cellular localization and the regulation of expression of WCPS genes in various cells. Modulation of WCPS expression or function by inhibitors or activators of channel (pore) permeability could provide novel drugs or therapies in various diseases, from tropical parasitic disorders to genetic disease (e.g. cystic fibrosis), from obesity and metabolic diseases to cancer.

Acknowledgements The author acknowledges the collaboration over the past 30 years of all coauthors in their publications listed in references. The financial support from Romania (“Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-Napoca, Ministry of Education and Research, National Council for Higher Education Scientific Research, Academy of Medical Sciences, National Council for Science and Technology), UK (The Wellcome Trust, The British Council), USA (National Science Fondation), and Australia (Taronga Zoo, Sydney) for the work reviewed in this article is gratefully acknowledged. He thanks several distinguished colleagues for sending him publications used in the elaboration of this review and/or for critical reading of the manuscript: Eric Beitz (Tübingen, Germany), Cong Cao (Nanjing, China), Robert A. Fenton (Arhus, Denmark), Tamir Gonen (Boston, USA), Stefan Hohmann, Karin Linkvist and Martin Markström (Gothenburg, Sweden), Vincent J. Huber (Niigata, Japan), Xuejun Li (Beijing, China), Nancy Kaufman (Pitsburgh, USA), Christophe Maurel (Montpellier, France), Richard Naftalin (London, UK), Shigeyasu Tanaka and Masakazu Suzuki (Shizuoka, Japan), Aurel Popa-Wagner (Greifswald, Germany), An Tanghe (Leuven, Belgium), Chang Xiang Zhao, and Hong Ba Shao (Qingdao, China). He also thanks Mrs. Adina Chiş, Dr. Adrian Florea, and Mr. Radu Munteanu for secretarial help in preparation of the manuscript.

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