Literature References


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Literature References


- C.R.Walker; Bioidentical Hormone Replacement Therapy.

- J.T.Hargrove, et al; An Alternative Method of Hormone Replacement Therapy Using the Natural Sex Steroids.

- J.T.Hargrove, et al; Menopause

M. Taylor; Alternative to Conventional Hormone Replacement Therapy.

- J.T. Hargrove, et al; Menopausal Hormone Replacement Therapy with Continuous Daily Oral Micronized Estradiol and Progesterone.

- M. Ahlgrimm; Natural Hormone Replacement: Individualized Treatment vs. AOne-size-fits-all
@ Therapy.

- D. Moskowitz; Changing Views: The Emergence and Efficacy of Natural Hormones in the Treatment of Menopause.

- B de Lignières, et al; Risks and Benefits of Hormone Replacement Therapy.

- B de Lignières, et al; Pharmacodynamics of Oestrogens and Progestogens.

- The Basics of Natural HRT (PCCA Handout)

- A.R. Gaby; Preventing and Reversing Osteoporosis

- J.V. Wright, et al; Comparative Measurements of Serum Estriol, Estradiol, and Estrone in Non-pregnant, Premenopausal Women: A

Preliminary Investigation.

- T.L. Bush, et al; Estrogen Use and All-Cause Mortality.

ESTRIOL (General)

K.A Head; Estriol: Safety and Efficacy

- V.A. Tzingounis; Estriol in the Management of the Menopause.

- T.S. Yang; Efficacy and Safety of Estriol Replacement Therapy for Climacteric Women.

- A.H. Follingstad; Estriol the Forgotten Estrogen?

- K.Takahashi, et al; Safety and Efficacy of Oestriol for Symptoms of Natural or Surgically Induced Menopause.

- B.S. Katzenellenbogen; Biology and Receptor Interactions of Estriol and Estriol Derivatives In Vitro and In Vivo.

- C. Longcope; Estriol Production and Metabolism in Normal Women.


- M.E. Mendelsohn, et al; The Protective Effects of Estrogen on the Cardiovascular System.

- M.C. Snabes, et al; Physiologic Estradiol Replacement Therapy and Cardiac Structure and Function in Normal Postmenopausal

Women: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.

- T. Pelzer, et al; Estrogen Effects in the Heart.

- L. Mosca; The Role of Hormone Replacement Therapy in the Prevention of Postmenopausal Heart Disease.

- F.P. Chen, et al; Comparison of transdermal and oral estrogen-progestin replacement therapy: effects on cardiovascular risk factors.

- J.D. Wagner; Rationale for Hormone Replacement Therapy in Atherosclerosis Prevention.

- M. Cushman, et al; Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins: The Postmenopausal Estrogen/Progestin

Intervention (PEPI) Study.

- H. Seeger, et al; Effect of Medroxyprogesterone Acetate and Norethisterone on Serum-Stimulated and Estradiol-Inhibited Proliferation

of Human Coronary Artery Smooth Muscle Cells.

- F. Grodstein, et al; Postmenopausal Hormone Therapy and Mortality.

- Winkler, et al; Affects of Androgens on Haemostatis

- The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial.

- JAMA, Jan. 1995; The Writing Group for the PEPI Trial; Effects of Estrogen or Estrogen/Progestin Regimens on Heart Disease - Risk

Factors in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial.

- A. Karjalainen, et al; Metabolic Changes Induced by Peroral Oestrogen and Transdermal Oestradiol Gel Therapy.

- N. Borglin, et al; Oral Treatment of Menopausal Symptoms with Natural Oestrogens - Experiences with a New Series of Oestrogens

and Oestrogen-Gestagen Combinations.

- B.W. Walsh, et al; Effects of Postmenopausal Hormone Replacement with Oral and Transdermal Estrogen on High Density Lipoprotein


- C. Haines, et al; Effect of Oral Estradiol on Lp(a) and Other Lipoproteins in Postmenopausal Women. A Randomized, Double-blind, Placebo-controlled, Crossover Study

- H. Itoi, et al; Comparison of the Long-Term Effects of Oral Estriol With The Effects of Conjugated Estrogen on Serum Lipid Profile in

early Menopausal Women.

- A. Dewell, et al; The Effects of Soy-Derived Phytoestrogens on Serum Lipids and Lipoproteins in Moderately Hypercholesterolemic

Postmenopausal Women.


- The North American Menopause Society; Postmenopausal Osteoporosis.

- D. Altkorn, et al; Treatment of Postmenopausal Osteoporosis.

- G.P. Dalsky; et al; Weight-Bearing Exercise Training and Lumbar Bone Mineral Content in Postmenopausal Women.

- X. Deng, et al; Correlation Between Bone Mineral Density and Sexual Hormones in Healthy Chinese Women.

- M.E. Nelson, et al; Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures.

- J.C. Prior, et al; Spinal Bone Loss and Ovulatory Disturbances.

- E.O. Abu, et al; The Localization of Androgen Receptors in Human Bone.

- I.R. Reid; The Roles of Calcium and Vitamin D in the Prevention of Osteoporosis.

- D. Feskanich, et al; Milk Dietary Calcium, and Bone Fractures in Women: A 12-Year Prospective Study.


- R. Lindsay; The Role of Estrogen in the Prevention of Osteoporosis.

- H. Minaguchi, et al.; Effect of Estriol on Bone Loss in Postmenopausal Japanese Women: A Multicenter Prospective Open Study.

- M. Nozaki, et al; Usefulness of Estriol for the Treatment of Bone Loss in Postmenopausal Women.

- A. Nishibe, et al; Effect of Estriol and Bone Mineral Density of Lumbar Vertebrae in Elderly and Postmenopausal Women.

- B. Ettinger, et al; The Waning Effect of Postmenopausal Estrogen Therapy on Osteoporosis.

- T. Hayaski, et al; Estriol (E3) Replacement Improves Endothelial Function and Bone Mineral Density in Very Elderly Women.

- H. Itoi, et al; Comparison of the long-term effects of oral estriol with the effects of conjugated estrogen, 1-a-hydroxyvitamin D3, and

calcium lactate on vertebral bone loss in early menopausal women.

- R. Raz, et al.; A Controlled Trial of Intravaginal Estriol in Postmenopausal Women with Recurrent Urinary Tract Infections.

- A.L. Kirkengen, et al.; Oestriol in the Prophylactic Treatment of Recurrent Urinary Tract Infections in Postmenopausal Women.

- J.B. Schmidt, et al.; Treatment of Skin Aging with Topical Estrogens.


- B.S. McEwen, et al; Eestrogen Actions in the Central Nervous System.

- J.E. Shepherd; Effects of Estrogen on Cognition, Mood, and Degenerative Brain Diseases.

- B.B. Sherwin; Oestrogen and Cognitive Function Throughout the Female Lifespan.

- B.B. Sherwin; Estrogen Effects on Cognition in Menopausal Women.

- P.M. Maki, et al; Longitudinal Effects of Estrogen Replacement Therapy on PET Cerebral Blood Flow and Cognition.

- B.B. Sherwin; Estrogenic Effects on Memory in Women.

- S.E. Shaywitz, et al; Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks.

- S.J. Birge; Is There a Role for Estrogen Replacement Therapy in the Prevention and Treatment of Dementia?

- B.B. Sherwin; Can Estrogen Keep You Smart? Evidence From Clinical Studies.

- S. Ramsay; The Lancet, Stroke Contributes to Women=s Higher Mortality After Cardiac Surgery.


- D. Ward; Natural Progesterone: The AFeel-Good@ Hormone.

- B. de Lignières; Oral Micronized Progesterone.

- J.T. Martorano, et al; Differentiating Between natural Progesterone and Synthetic Progestins: Clinical Implications for Premenstrula

Syndrome and Perimenopause Management.

- R. Barentsen, et al; Progestogens: Pharmacological Characteristics and Clinically Relevant Differences.

- W.S. Maxson, et al; Bioavailability of Oral Micronized Progesterone.

- T.R. Norman, et al; Comparative Bioavailability of Orally and Vaginally Administered Progesterone.

- C.J. Richards-Kustan, et al; Diagnosis and Management of Perimenopausal and Postmenopausal Bleeding.

- E. Cicinelli, et al; Effects of Progesterone Administered by Nasal Spray on the Human Postmenopausal Endometrium.

- R.A. Miiles, et al.; Pharmacokinetics and Endometrial Tissue Levels of Progesterone After Administration by Intramuscular and Vaginal

Routes: A Comparative Study.

- J.N. Anasti, et al; Topical Progesterone Cream Has Antiproliferative Effect on Estrogen-Stimulated Endometrium.

- W. Cheng, et al; Two Antiatherogenic Effects of Progesterone on Human Macrophages; Inhibition of Cholestryl Ester Synthesis and

Block of Its Enhancement by Glucocoricoids.

- H. Desai; Natural Progesterone Therapy in the Treatment of Preeclampsia.

- R.L. Landau, et al.; Inhibition of the Sodium-Retaining Influence of Aldosterone by Progesterone.

- J.C. Laidlaw, et al.; The Influence of Estrogen and Progesterone on Aldosterone Excretion.

- R.L. Landau, et al; The Catabolic and Nutriuretic Effects of Progesterone in Man.

- P. Corvol, et al; Effect of Progesterone and Progestins on Water and Salt Metabolism.

- A. Tavaniotou, et al; Comparison between different routes of progesterone administration as luteal phase support in infertility


- J.C. Prior; Progesterone as a Bone-Trophic Hormone.

- H.B. Leonetti, et al.; Transdermal Progesterone Cream for Vasomotor Symptoms and Postmenopausal Bone Loss.

- J.R. Lee; Is Natural Progesterone the Missing Link in Osteoporosis Prevention and Treatment?

- J.C. Prior, et al; Progesterone and the Prevention of Osteoporosis.

- I.I. Bolaji, et al; Low-Dose Progesterone Therapy in Oestrogenised Postmenopausal Women: Effects on Plasma Lipids, Lipoproteins and Liver

Function Parameters.

- E. Darj, et al; Liver Metabolism During Treatment with Estradiol and Natural Progesterone.

- E.S. Arafat; Sedative and Hypnotic Effects of Oral Administration of Micronized Progesterone May Be Mediated Through Its


- E.W. Freeman, et al; Anxiolytic Metabolites of Progesterone: Correlation With Mood and Performance Measures Following Oral

Progesterone Administration to Healthy Female Volunteers.

- R. Rupprecht; Neuroactive Steroids: Mechanisms of Action and Neuropsychopharmacological Perspectives.

- A.G Herzog, et al; Charles A. Dana Research Institute, Progesterone therapy in women with complex partial and secondary generalized


- S.R. Davis; The Clinical Use of Androgens in Female Sexual Disorders.

- G.A. Laughlin, et al; Hysterectomy, Oophorectomy, and Endogenous Sex Hormone Levels in Older Women: The Rancho Bernardo


- R.L. Young; Androgens in Postmenopausal Therapy?

- K.K. Miller; Androgen Deficiency in Women.

- P.R. Casson, et al; Effect of Postmenopausal Estrogen Replacement on Circulating Androgens.

- B.A. Gower, et al; Associations among Oral Estrogen Use, Free Testosterone Concentration, and Lean Body Mass among

Postmenopausal Women.

- J.L. Shifren, et al.; Transdermal Testosterone Treatment in Women with Impaired Sexual Function After Oophorectomy.

- S. Rako; Testosterone Deficiency and Supplementation for Women: What Do We Need to Know?

- S.R. Davis; Androgens and Female Sexuality.

- K. Palacioz; Testosterone Replacement For Women.

- B.B.Sherwin, et al; Androgen Enhances Sexual Motivation in Females: A Prospective, Crossover Study of Sex Steroid Administration in

the Surgical Menopause.

- N.B. Watts, et al; Comparison of Oral Estrogens and Estrogens Plus Androgen on Bone Mineral Density, Menopausal Symptoms, and

Lipid-Lipoprotein Profiles in Surgical Menopause.

- E.Barrett-Connor, et al; A Two-Year, Double-Blind Comparison of Estrogen-Androgen and Conjugated Estrogens in Surgically

Menupausal Women.

- K.K. Miller, et al; Androgen Deficiency in Women with Hypopituitarism.

- K.Miller, et al; Transdermal Testosterone Administration in Women with Acquired Immunodeficiency Syndrome Wasting: A Pilot Study.

- H.G. Burger, et al; A Prospective Longitudinal Study of Serum Testosterone Dehydroepiandrosterone Sulfate, and Sex Hormone-

Binding Globulin Levels Through the Menopause Transition.

- P. Ebeling, et al.; Physiological Importance of Dehydroepiandrosterone.

- P.J. Hunt, et al; Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison=s Disease in a Randomized,

Double Blind Trial.

- A.J. Morales, et al.; Effects of Replacement Dose of Dehydroepiandrosterone in Men and Women of Advancing Age.

- S. Legrain, et al; Dehydroepiandrosterone Replacement Administration Pharmacokinetic and Pharmacodynamic Studies in Healthy

Elderly Subjects.

- K.T. Barnhart, et al; The Effect of Dehydroepiandrosterone Supplementation to Symptomatic Perimenopausal Women on Serum

Endocrine Profiles, Lipid Parameters, and Health-Related Quality of Life.

- F. Callies, et al; Dehydroepiandrosterone Replacement in Women With Adrenal Insufficiency: Effects on Body Composition, Serum

Leptin, Bone Turnover, and Exercise Capacity.

- J.C. Achermann, et al; Dehydroepiandrosterone Replacement for Patients With Adrenal Insufficiency.

- P.J. Hunt, et al; Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison=s Disease in a Randomized,

Double Blind Trial.

- F. Labrie, et al; Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in

Postmenopausal Women.

- C.C. Slater, et al; Comparison of Estrogen and Androgen Levels After Oral Estrogen Replacement Therapy.

- A. Tuiten, et al; Time Course of Effects of Testosterone – Administration on Sexual Arousal in Women

- A.J. Morales, et al; The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex

steroids, body composition and muscle strength in age-advanced men and women.


- H. Kuhl; Pharmacokinetics of Oestrogens and Progestogens.

- T. Ojasoo, et al; Affiliations Among Steroid Receptors as Revealed by Multivariate Analysis of Steroid Binding Data.

- F. Devenuto, et al; Human Erythrocyte Membrane. Uptake of Progesterone and Chemical Alterations.

- P. Koefoed, et al; The Permeability of the Human Red Cell Membrane to Steroid Sex Hormones.

- R. Hiramatsu, et al; Erythrocyte-Associated Cortisol: Measurement, Kinetics of Dissociation, and Potential Physiological Significance.

- M.E Johnson, et al; Permeation of Steroids Through Human Skin.

- K. Nahoul, et al; Profiles of Plasma Estrogens, Progesterone and Their Metabolites After Oral or Vaginal Administration of Estradiol or


- M. Babu, et al; Twenty Two Weeks of Trandermal Estradiol Incrases Sex Hormone-Binding Globulin in Surgical Menopausal


- R. Pasquali, et al; Determinants of Sex Hormone-Binding Globulin Blood Concentrations in Premenopausal and Postmenopausal

Women With Different Estrogen Status.

- N. Moghrabi, et al; 17 Beta-Hydroxysteroid Dehydrogenases: Physiological Roles in Health and Disease.

- F. DeVenuto, et al; Pub Med, Interaction of Progesterone and Aldosterone with Red Blood Cells of the Rat.

- A.J. O’Sullican, et al; Route-Dependent Endocrine and Metabolic Effects of Estrogen Replacement Therapy.

- Tuiten, et al; Morales Articles


- K. Acheson, et al.; The Thyroid Gland.

- R. Arem, et al.; Subclinical Hypothyroidism: Epidemiology, Diagnosis, and Significance.

- L. Wartofsky; The Scope and Impact of Thyroid Disease.

- M. A. Laycock, et al.; The Neuromuscular Effects of Hypothyroidism.

- R. Kellman; Your Thyroid May be Low, After All.

- A. D. Toft; Thyroid Hormone Replacement—One Hormone or Two?

- R. Bunevicius, et al.; Effects of Thyroxine as Compared with Thyroxine Plus Triiodothyronine in Patients with Hypothyroidism.

- J. E. Haddow, et al.; Maternal Thyroid Deficiency During Pregnancy and Subsequent Neuropsychological Development of the Child.

- D. E. Stewart, et al.; Thyroid Function in Psychosis Following Childbirth.

- P. J. Schmidt, et al.; Thyroid Function in Women with Premenstrual Syndrome.

- R. Chadarevian, et al.; Components of the Fibrinolytic System Are Differently Altered in Moderate and Severe Hypothyroidism.

- B.M. Arafah, et al; Increased Need for Thyroxine in Women with Hypothyroidism during estrogen therapy.


- M. F. Levitt, et al.; Fluid and Electrolyte.

- D. R. Jacobs, et al.; A Salt-losing Steroid.

- D. R. Jacobs; Natriuretic Activity of 17-hydroxyprogesterone in Man.

- W. R. Beisel, et al.; Interrelations Between Adrenocortical Functions and Infectious Illness.

- W. M. Jefferies, et al.; Treatment of Ovarian Dysfunction with Small Doses of Cortisone or Hydrocortisone.

- W. M. Jefferies; Treatment of Ovarian Dysfunction with Cortisone or Estrogen.

- W. M. Jefferies; Thyroid and Adrenal Problems in Gynecology.

- W. M. Jefferies; Low Dosage Glucocorticoid Therapy.; An Appraisal of its Safety and Mode of Action in Clinical Disorders Including

Rheumatoid Arthris.

- S. Shuster, et al.; Pituitary and Adrenal Function During Administration of Small Doses of Glucocorticoids.

- W. M. Jefferies; Cortisol and Immunity.

- B. Zumoff, et al.; Hormone Profiles in Hormone-Dependent Cancers.

- B. Zumoff; Hormonal Profiles in Women with Breast Cancer.

- T.A. Sellers, et al.; The Role of Hormone Replacement Therapy in the Risk for Breast Cancer and Total Mortality in Women with a Family

History of Breast Cancer.

- R.C. Guzman, et al; Hormonal Prevention of Breast Cancer: Mimicking the Protective Effect of Pregnancy.

- C. Gajdos, et al; Breast Cancer Diagnosed During Hormone Replacement Therapy.

- C. Schairer, et al; Menopausal Estrogen and Estrogen-Progestin Replacement Therapy and Breast Cancer Risk.

- C. Rodriguez, et al; Estrogen Replacement Therapy and Ovarian Cancer Mortality in a Large Prospective Study of US Women.

- J.A. Eden, et al; A Case-Control Study of Combined Continuous Estrogen-Progestin Replacement Therapy Among Women With a

Personal History of Breast Cancer.

- M.M. Madeleine, et al; Human Papillomavirus and Long-Term Oral Contraceptive Use Increase the Risk of Adenocarcinoma in Situ of

the Cervix.

- G.E.Hale, et al; Clinical Review 139, Endometrial Cancer: Hormonal Factors, the Perimenopausal “Window of Risk,” and Isoflavones.

- Chi-Ling Chen, et al; Hormone Replacement Therapy in Relation to Breast Cancer

- F. McLellan, et al; The Lancet, Independent US panel fans debate on mammography.

- G. Kolata, et al; The New York Times, X-Ray Vision in Hindsight: Science, Politics and the Mammogram.

- The Associated Press, More Debate Over Mammograms.

- C. Gorman, et al; TIME, Rethinking Breast Cancer.

- K.J. Chang, et al; Influences of Percutaneous Administration of Estradiol and Progesterone on Human Breast Epithelial Cell Cycle In


- L.D. Cowan, et al; Breast Cancer Incidence in Women with a History of Progesterone Deficiency.

- P.E. Mohr, et al; Serum Progesterone and Prognosis in Operable Breast Cancer.

- B. Formby, et al; Progesterone Inhibits Growth and Induces Apotosis in Breast Cancer Cells: Inverse Effects on Bcl-2 and p53.

- S.Z. Bu, et al; Progesterone Induces Apoptosis and Up-Regulation of P53 Expression in Human Ovarian Carcinoma Cell Lines.

- K. Boman, et al; The Influence of Progesterone and Androgens on the Growth of Endometrial Carcinoma.


- H.M. Lemon; Oestriol and Prevention of Breast Cancer.

- H.M. Lemon, et al; Reduced Estriol Excretion in Patients with Breast Cancer Prior to Endocrine Therapy.

- H.M. Lemon; Pathophysiologic Considerations in the Treatment of Menopausal Patients with Oestrogens; the Role of Estriol in the

Prevention of Mammary Carcinoma

- M. Melamed, et al; Molecular and Kinetic Basis for the Mixed Agonist/Antagonist Activity of Estriol.

- H.M. Lemon; Antimammary Carcinogenic Activity of 17-Alpha-Ethinyl Estriol.

- L.F. Dickinson, et al; Estrogen Profiles of Oriental and Caucasian Women in Hawaii.

- J.D. Yager, et al; Molecular Mechanisms of Estrogen Carcinogenesis.

- H.L. Bradlow, et al; 16 Alpha-hydroxylantion of Estradiol: A Possible Risk Marker for Breast Cancer.

- E.L. Cavalieri, et al; Molecular Origin of Cancer: Catechol Estrogen-3,4-Quinones as Endogenous Tumor Initiators.

- H.L. Bradlow, et al; 2-Hydroxyestrone: The AGood Estrogen@.

- L. Shen, et al; Alkylation of 2'-Deoxynucleosides and DNA by the Premarin Metabolite 4-Hydroxyequilenin Semiquinone Radical.

- H.T. Zhu, et al; The Carcinogenic Activity of Ethinyl Estrogens Is Determined by Both Their Hormonal Characteristics and Their

Conversion to Catechol Metabolites.

- T. Suzuki, et al; 5 Alpha-Reductases in Human Breast Carcinoma: Possible Modulator of in Situ Androgenic Actions.


- J.V. Wright; Cabbages, Broccoli, et al., Versus Sex Hormone Related Cancers.

- H.L. Bradlow, et al; Indole-3-Carbinol. A Novel Approach to Breast Cancer Prevention.

- N.T. Telang, et al; Inhibition of Proliferation and Modulation of Estradiol Metabolism: Novel Mechanisms for Breast Cancer Prevention

by the Phytochemical Indole-3-Carbinol.

- I. Chen, et al; Aryl Hydrocarbon Receptor-Mediated Antiestrogenic and Antitumorigenic Activity of Diindolylmethane.

- D.C. Hall; Nutritional Influences on Estrogen Metabolism.

- H. Adlercreutz; Phytoestrogens: Epidemiology and a Possible Role in Cancer Protection.

- L.W. Lu, et al; Decreased Ovarian Hormones During a Soya Diet: Implications for Breast Cancer Prevention.

- T.L. Dog, et al; Traditional and Alternative Therapies for Breast Cancer.

- R.A. Wiseman; Breast Cancer Hypothesis: A Single Cause for the Majority of Cases.

- P. Lichtenstein, et al; Environmental and Heritable Factors in the Causation of Cancer.


- A.G. Schwartz; Cancer Chemoprevention with the Adrenocorticosteroid DHEA and Structural Analogs.

- M.J. Reed; Breast Cancer and the Role of Cytokines in Regulating Estrogen Synthesis: An Emerging Hypothesis.

- J. S. Flier, et al.; Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance.

- A. P. Corcos, et al.; Correction by Bromocriptine of Hypothalamic Dysfunction and Post-Prandial Hypoglycemic Symptoms in a 31-

Year-Old Woman.

- Steroids Serum Levels In Humans

- Pituitary Hormones Levels in Humans

- Thyroid Hormones Levels in Humans

- K. Modelska, et al; Clinical Review, Tibolone for Postmenopausal Women: Systematic Review of Randomized Trials.

- M. Sohn, et al; Ginkgo Biloba Extract in the Therapy of Erectile Dysfunction


- A.J. Cohen, et al; Ginkgo Shown Useful in Sexual Dysfunction Caused by Antidepressant Drugs.

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