Online supplement



Download 0.69 Mb.
Page1/7
Date conversion23.12.2016
Size0.69 Mb.
  1   2   3   4   5   6   7
ONLINE SUPPLEMENT


Supplementary Table I: Literature Search Strategies
Additional Figures - Forest Plots, Funnel Plots and Stratified Analysis for Study Size and References
Supplementary Table II: Study Characteristics

Supplementary Table I: Literature Search Strategies





Database

Search Strategy







PubMed

Three strategies:

1.

((("pre-eclampsia"[mesh] OR "pre-eclampsia"[tw] OR preeclampsia[tw] OR "EPH Complex"[tw] OR "EPH Gestosis"[tw] OR "EPH Toxemias"[tw] OR "EPH Toxemia"[tw] OR "Pregnancy Toxemias"[tw] OR "Pregnancy Toxemia"[tw] OR "Proteinuria-Edema-Hypertension Gestosis"[tw] OR "Proteinuria Edema Hypertension Gestosis"[tw] OR "Edema-Proteinuria-Hypertension Gestosis"[tw] OR "Edema Proteinuria Hypertension Gestosis"[tw] OR "Hypertension-Edema-Proteinuria Gestosis"[tw] OR "Hypertension Edema Proteinuria Gestosis"[tw] OR "Hypertension, Pregnancy-Induced"[majr:noexp] OR "hypertensive disorder complicating pregnancy"[ti] OR Pregnancy Induced Hypertension[ti] OR "gestational hypertension"[ti]) AND (gene OR genes OR Polymorphism OR Polymorphisms OR dna OR genome OR genomes OR genomic OR ("Genetic Phenomena"[mesh] NOT "Gene Expression Regulation"[mesh]) OR "factor V leiden" OR "Factor V"[mesh])) OR "Pre-Eclampsia/genetics"[Majr]) AND (english[la] OR dutch[la])

2.

("pre-eclampsia"[mesh] OR "pre-eclampsia"[tw] OR preeclampsia[tw] OR "EPH Complex"[tw] OR "EPH Gestosis"[tw] OR "EPH Toxemias"[tw] OR "EPH Toxemia"[tw] OR "Pregnancy Toxemias"[tw] OR "Pregnancy Toxemia"[tw] OR "Proteinuria-Edema-Hypertension Gestosis"[tw] OR "Proteinuria Edema Hypertension Gestosis"[tw] OR "Edema-Proteinuria-Hypertension Gestosis"[tw] OR "Edema Proteinuria Hypertension Gestosis"[tw] OR "Hypertension-Edema-Proteinuria Gestosis"[tw] OR "Hypertension Edema Proteinuria Gestosis"[tw] OR "Hypertension, Pregnancy-Induced"[majr:noexp] OR "hypertensive disorder complicating pregnancy"[ti] OR Pregnancy Induced Hypertension[ti] OR "gestational hypertension"[ti]) AND (gene OR genes OR polymorphism OR polymorphisms OR genetic OR genetical OR genetically) AND (Angiotensin-converting enzyme OR ace OR angiotensin-converting enzymes OR "i/d" OR rs4646994 OR AGT OR angiotensin OR M235T OR rs699 OR Thr174Met OR rs4762 OR "apolipoprotein E" OR APOE OR epsilon2 OR rs429358 OR rs7412 OR "angiotensin II receptor" OR AGTR1 OR AGTR OR A1166C OR "cytotoxic T-lymphocyte-associated protein 4" OR CTLA4 OR A49G OR rs231775 OR eNOS OR NOS3 OR "nitric oxide synthase 3" OR "endothelial nitric oxide synthase" OR Glu298Asp OR rs1799983 OR T786C OR rs2070744 OR 27bp OR "4ab" OR "4 a b" OR "microsomal epoxide hydrolase 1" OR EPHX OR 113TyrHis OR rs2549782 OR "endoplasmic reticulum

aminopeptidase 2" OR ERAP2 OR Asn392Lys OR rs2549782 OR "Factor V" OR FV OR F5 OR R485K OR G1628
A OR "Factor V Leiden" OR "FVL" OR G1691A OR rs6025 OR "glutathione S-transferase P" OR GSTP1 OR Ile105Val OR rs1695 OR "human leukocyte antigen" OR "HLA" OR "HLA G" OR "interleukin 10" OR "IL 10" OR IL-10 or G1082A OR rs1800896 OR "lipoprotein lipase" OR LPL OR N291S OR rs268 OR "methylenetetrahydrofolate reductase" OR MTHFR OR C677T OR rs1801133 OR "serpin peptidase inhibitor" OR "plasminogen activator inhibitor 1" OR SERPINE1 OR "PAI-1" OR "PAI1" OR "4G/5G" OR "4g 5g" OR rs1799768 OR "coagulation factor II" OR "thrombin" OR F2 or PT or PTM OR G20210A OR rs1799963 OR "transforming growth factor beta" OR "TGF beta" OR TGFB OR "Leu10Pro" OR rs1800470 OR "tumor necrosis factor alpha" OR "TNF-alpha" OR TNFA OR C850T OR C1037T OR rs1799724 OR G308A OR rs1800629) AND (english[la] OR dutch[la])

3.

("pre-eclampsia"[mesh] OR "pre-eclampsia"[tw] OR preeclampsia[tw] OR "EPH Complex"[tw] OR "EPH Gestosis"[tw] OR "EPH Toxemias"[tw] OR "EPH Toxemia"[tw] OR "Pregnancy Toxemias"[tw] OR "Pregnancy Toxemia"[tw] OR "Proteinuria-Edema-Hypertension Gestosis"[tw] OR "Proteinuria Edema Hypertension Gestosis"[tw] OR "Edema-Proteinuria-Hypertension Gestosis"[tw] OR "Edema Proteinuria Hypertension Gestosis"[tw] OR "Hypertension-Edema-Proteinuria Gestosis"[tw] OR "Hypertension Edema Proteinuria Gestosis"[tw] OR "Hypertension, Pregnancy-Induced"[majr:noexp] OR "hypertensive disorder complicating pregnancy"[ti] OR Pregnancy Induced Hypertension[ti] OR "gestational hypertension"[ti]) AND (gene OR genes OR polymorphism OR polymorphisms OR genetic OR genetical OR genetically) AND ("activin receptor type 2A of activin A receptor type IIA" OR ACVR2A OR ACTRII OR adiponectin OR ADIPOQ OR "apolipoprotein J" OR clusterin OR "APO J" OR CLU OR "androgen receptor" OR AR OR "angiotensin type 2 receptor" OR AT2R OR "beta-2 adrenoceptor" OR "beta-2 adrenergic receptor" OR ADRB2 OR "beta-3 adrenergic receptor" OR ADRB3 OR "complement C3" OR C3 OR CD14 OR "cannabinoid receptor 1" OR CNR1 OR "collagen type 1 alpha 1" OR "COL1A1" OR "complement receptor 1" OR CR1 OR CD35 OR "c-reactive protein" OR CRP OR "cytochrome b 245 alpha" OR CYBA OR "aldosterone synthase" OR CYP11B2 OR "cytochrome P450 17A1" OR CYP17A1 OR "endothelin 1" OR EDN1 OR "epidermal growth factor" OR EGF OR "epithelial sodium channel" OR enac OR "factor XI" or "factor 11" OR F11 OR FXI OR "fms-related tyrosine kinase 1" OR "Flt-1" OR "FLT1" OR "G protein beta 3" OR "GN beta 3" OR "gycoprotein IIIa" OR "GP IIIa" OR "GPIIIa" OR haptoglobin OR hp OR "heat shock protein 1b" OR HSPA1B OR "heat shock protein 1-like" OR HSPA1L OR "inducible T-cell co-stimulator" OR ICOS OR "interferon gamma receptor 1" OR IFNGR1 OR "interleukin 1 alpha" OR "IL-1 alpha" OR "interleukin 1 receptor antagonist" OR IL1RN OR "interleukin 4" OR "IL-4" OR "inducible nitric oxide synthase" OR "iNOS" OR "killer cell immunoglobulin-like receptor" OR KIR2DL5 OR KIR3DL2 OR leptin OR LEP OR "leptin receptor" OR LEPR OR "mannose-binding lectin" OR MBL OR "matrix metallopeptidase 9" OR "MMP9" OR myeloperoxidase OR MPO OR "nuclear receptor" OR NR1H2 OR "pregnancy-associated plasma protein A" OR "PAPP-A" OR "paraoxonase 1" OR PON1 OR prolylcarboxypeptidase OR PRCP OR renin OR REN or "selenoprotein S" or SEPS1 OR "solute carrier" OR SLC4A1 OR SLC9A3 OR "solute carrier organic anion transporter family" OR SLCO4C1 OR "tachykinin receptor 3" OR TACR3 OR VEGF OR "vascular endothelial growth factor" OR "von Willebrand factor" OR vWF) AND (english[la] OR dutch[la])









Embase (OVID-version)

(preeclampsia/ OR (preeclampsia OR "EPH Complex" OR "EPH Gestosis" OR "EPH Toxemias" OR "EPH Toxemia" OR "Pregnancy Toxemias" OR "Pregnancy Toxemia" OR "Proteinuria-Edema-Hypertension Gestosis" OR "Proteinuria Edema Hypertension Gestosis" OR "Edema-Proteinuria-Hypertension Gestosis" OR "Edema Proteinuria Hypertension Gestosis" OR "Hypertension-Edema-Proteinuria Gestosis" OR "Hypertension Edema Proteinuria Gestosis").mp) AND (exp Gene/ OR gene.mp OR genom*.mp OR genes.mp OR exp genetic polymorphism/ OR polymorphism*.mp OR dna.mp OR exp dna/ OR (exp *Heredity/ NOT exp Gene Expression/)) AND (Angiotensin-converting enzyme OR ace OR angiotensin-converting enzymes OR "i/d" OR rs4646994 OR AGT OR angiotensin OR M235T OR rs699 OR Thr174Met OR rs4762 OR "apolipoprotein E" OR APOE OR epsilon2 OR rs429358 OR rs7412 OR "angiotensin II receptor" OR AGTR1 OR AGTR OR A1166C OR "cytotoxic T-lymphocyte-associated protein 4" OR CTLA4 OR A49G OR rs231775 OR eNOS OR NOS3 OR "nitric oxide synthase 3" OR "endothelial nitric oxide synthase" OR Glu298Asp OR rs1799983 OR T786C OR rs2070744 OR 27bp OR "4ab" OR "4 a b" OR "microsomal epoxide hydrolase 1" OR EPHX OR 113TyrHis OR rs2549782 OR "endoplasmic reticulum
aminopeptidase 2" OR ERAP2 OR Asn392Lys OR rs2549782 OR "Factor V" OR FV OR F5 OR R485K OR G1628

A OR "Factor V Leiden" OR "FVL" OR G1691A OR rs6025 OR "glutathione S-transferase P" OR GSTP1 OR Ile105Val OR rs1695 OR "human leukocyte antigen" OR "HLA" OR "HLA G" OR "interleukin 10" OR "IL 10" OR IL-10 or G1082A OR rs1800896 OR "lipoprotein lipase" OR LPL OR N291S OR rs268 OR "methylenetetrahydrofolate reductase" OR MTHFR OR C677T OR rs1801133 OR "serpin peptidase inhibitor" OR "plasminogen activator inhibitor 1" OR SERPINE1 OR "PAI-1" OR "PAI1" OR "4G/5G" OR "4g 5g" OR rs1799768 OR "coagulation factor II" OR "thrombin" OR F2 or PT or PTM OR G20210A OR rs1799963 OR "transforming growth factor beta" OR "TGF beta" OR TGFB OR "Leu10Pro" OR rs1800470 OR "tumor necrosis factor alpha" OR "TNF-alpha" OR TNFA OR C850T OR C1037T OR rs1799724 OR G308A OR rs1800629 OR "activin receptor type 2A of activin A receptor type IIA" OR ACVR2A OR ACTRII OR adiponectin OR ADIPOQ OR "apolipoprotein J" OR clusterin OR "APO J" OR CLU OR "androgen receptor" OR AR OR "angiotensin type 2 receptor" OR AT2R OR "beta-2 adrenoceptor" OR "beta-2 adrenergic receptor" OR ADRB2 OR "beta-3 adrenergic receptor" OR ADRB3 OR "complement C3" OR C3 OR CD14 OR "cannabinoid receptor 1" OR CNR1 OR "collagen type 1 alpha 1" OR "COL1A1" OR "complement receptor 1" OR CR1 OR CD35 OR "c-reactive protein" OR CRP OR "cytochrome b 245 alpha" OR CYBA OR "aldosterone synthase" OR CYP11B2 OR "cytochrome P450 17A1" OR CYP17A1 OR "endothelin 1" OR EDN1 OR "epidermal growth factor" OR EGF OR "epithelial sodium channel" OR enac OR "factor XI" or "factor 11" OR F11 OR FXI OR "fms-related tyrosine kinase 1" OR "Flt-1" OR "FLT1" OR "G protein beta 3" OR "GN beta 3" OR "gycoprotein IIIa" OR "GP IIIa" OR "GPIIIa" OR haptoglobin OR hp OR "heat shock protein 1b" OR HSPA1B OR "heat shock protein 1-like" OR HSPA1L OR "inducible T-cell co-stimulator" OR ICOS OR "interferon gamma receptor 1" OR IFNGR1 OR "interleukin 1 alpha" OR "IL-1 alpha" OR "interleukin 1 receptor antagonist" OR IL1RN OR "interleukin 4" OR "IL-4" OR "inducible nitric oxide synthase" OR "iNOS" OR "killer cell immunoglobulin-like receptor" OR KIR2DL5 OR KIR3DL2 OR leptin OR LEP OR "leptin receptor" OR LEPR OR "mannose-binding lectin" OR MBL OR "matrix metallopeptidase 9" OR "MMP9" OR myeloperoxidase OR MPO OR "nuclear receptor" OR NR1H2 OR "pregnancy-associated plasma protein A" OR "PAPP-A" OR "paraoxonase 1" OR PON1 OR prolylcarboxypeptidase OR PRCP OR renin OR REN or "selenoprotein S" or SEPS1 OR "solute carrier" OR SLC4A1 OR SLC9A3 OR "solute carrier organic anion transporter family" OR SLCO4C1 OR "tachykinin receptor 3" OR TACR3 OR VEGF OR "vascular endothelial growth factor" OR "von Willebrand factor" OR vWF).mp AND (english OR dutch).la









Web of Science

TS=("pre-eclampsia" OR preeclampsia OR "EPH Complex" OR "EPH Gestosis" OR "EPH Toxemias" OR "EPH Toxemia" OR "Pregnancy Toxemias" OR "Pregnancy Toxemia" OR "Proteinuria-Edema-Hypertension Gestosis" OR "Proteinuria Edema Hypertension Gestosis" OR "Edema-Proteinuria-Hypertension Gestosis" OR "Edema Proteinuria Hypertension Gestosis" OR "Hypertension-Edema-Proteinuria Gestosis" OR "Hypertension Edema Proteinuria Gestosis") AND TS=(gene OR genes OR genom* OR genetic* OR Polymorphism* OR dna) AND TS=(Angiotensin-converting enzyme OR ace OR angiotensin-converting enzymes OR "i/d" OR rs4646994 OR AGT OR angiotensin OR M235T OR rs699 OR Thr174Met OR rs4762 OR "apolipoprotein E" OR APOE OR epsilon2 OR rs429358 OR rs7412 OR "angiotensin II receptor" OR AGTR1 OR AGTR OR A1166C OR "cytotoxic T-lymphocyte-associated protein 4" OR CTLA4 OR A49G OR rs231775 OR eNOS OR NOS3 OR "nitric oxide synthase 3" OR "endothelial nitric oxide synthase" OR Glu298Asp OR rs1799983 OR T786C OR rs2070744 OR 27bp OR "4ab" OR "4 a b" OR "microsomal epoxide hydrolase 1" OR EPHX OR 113TyrHis OR rs2549782 OR "endoplasmic reticulum
aminopeptidase 2" OR ERAP2 OR Asn392Lys OR rs2549782 OR "Factor V" OR FV OR F5 OR R485K OR G1628

A OR "Factor V Leiden" OR "FVL" OR G1691A OR rs6025 OR "glutathione S-transferase P" OR GSTP1 OR Ile105Val OR rs1695 OR "human leukocyte antigen" OR "HLA" OR "HLA G" OR "interleukin 10" OR "IL 10" OR IL-10 or G1082A OR rs1800896 OR "lipoprotein lipase" OR LPL OR N291S OR rs268 OR "methylenetetrahydrofolate reductase" OR MTHFR OR C677T OR rs1801133 OR "serpin peptidase inhibitor" OR "plasminogen activator inhibitor 1" OR SERPINE1 OR "PAI-1" OR "PAI1" OR "4G/5G" OR "4g 5g" OR rs1799768 OR "coagulation factor II" OR "thrombin" OR F2 or PT or PTM OR G20210A OR rs1799963 OR "transforming growth factor beta" OR "TGF beta" OR TGFB OR "Leu10Pro" OR rs1800470 OR "tumor necrosis factor alpha" OR "TNF-alpha" OR TNFA OR C850T OR C1037T OR rs1799724 OR G308A OR rs1800629 OR "activin receptor type 2A of activin A receptor type IIA" OR ACVR2A OR ACTRII OR adiponectin OR ADIPOQ OR "apolipoprotein J" OR clusterin OR "APO J" OR CLU OR "androgen receptor" OR AR OR "angiotensin type 2 receptor" OR AT2R OR "beta-2 adrenoceptor" OR "beta-2 adrenergic receptor" OR ADRB2 OR "beta-3 adrenergic receptor" OR ADRB3 OR "complement C3" OR C3 OR CD14 OR "cannabinoid receptor 1" OR CNR1 OR "collagen type 1 alpha 1" OR "COL1A1" OR "complement receptor 1" OR CR1 OR CD35 OR "c-reactive protein" OR CRP OR "cytochrome b 245 alpha" OR CYBA OR "aldosterone synthase" OR CYP11B2 OR "cytochrome P450 17A1" OR CYP17A1 OR "endothelin 1" OR EDN1 OR "epidermal growth factor" OR EGF OR "epithelial sodium channel" OR enac OR "factor XI" or "factor 11" OR F11 OR FXI OR "fms-related tyrosine kinase 1" OR "Flt-1" OR "FLT1" OR "G protein beta 3" OR "GN beta 3" OR "gycoprotein IIIa" OR "GP IIIa" OR "GPIIIa" OR haptoglobin OR hp OR "heat shock protein 1b" OR HSPA1B OR "heat shock protein 1-like" OR HSPA1L OR "inducible T-cell co-stimulator" OR ICOS OR "interferon gamma receptor 1" OR IFNGR1 OR "interleukin 1 alpha" OR "IL-1 alpha" OR "interleukin 1 receptor antagonist" OR IL1RN OR "interleukin 4" OR "IL-4" OR "inducible nitric oxide synthase" OR "iNOS" OR "killer cell immunoglobulin-like receptor" OR KIR2DL5 OR KIR3DL2 OR leptin OR LEP OR "leptin receptor" OR LEPR OR "mannose-binding lectin" OR MBL OR "matrix metallopeptidase 9" OR "MMP9" OR myeloperoxidase OR MPO OR "nuclear receptor" OR NR1H2 OR "pregnancy-associated plasma protein A" OR "PAPP-A" OR "paraoxonase 1" OR PON1 OR prolylcarboxypeptidase OR PRCP OR renin OR REN or "selenoprotein S" or SEPS1 OR "solute carrier" OR SLC4A1 OR SLC9A3 OR "solute carrier organic anion transporter family" OR SLCO4C1 OR "tachykinin receptor 3" OR TACR3 OR VEGF OR "vascular endothelial growth factor" OR "von Willebrand factor" OR vWF) AND la=(english OR dutch)





Supplementary 2: Additional Figures - Forest Plots, Funnel Plots, Stratified Analysis for Study Size and References

Supplementary Figure 1a.

ACE rs4646994 forest plot.
References


Supplementary Figure 1b.

ACE rs4646994 funnel plot.

Begg test: p=0.044, Egger test: p=0.003.



Supplementary Figure 1c.

ACE rs4646994: studies subdivided according to study size.


Supplementary Figure 2a.

AGT rs699 forest plot.
References

** **



Supplementary Figure 2b.

AGT rs699 funnel plot.

Begg test: p=0.116, Egger test: p=0.109.


Supplementary Figure 3a.

Forest plot AGT rs4762.


References



Supplementary Figure 3b.

AGT rs4762 funnel plot.

Begg test: p=0.327, Egger test: p=0.316.





Supplementary Figure 4a.

APOE rs429358, rs7412 (E2 allele) forest plot.
References



Supplementary Figure 4b.

APOE rs429358, rs7412 (E2 allele) funnel plot.

Begg test: p=0.881, Egger test: p=0.331.





Supplementary Figure 5a.

AT1R rs5186 forest plot.
References



Supplementary Figure 5b.

AT1R rs5186 funnel plot.

Begg test: p=0.022, Egger test: p=0.044.




Supplementary Figure 6a.

CTLA4 rs231775 forest plot.
References


Supplementary Figure 6b.

CTLA4 rs231775 funnel plot.

Begg test: p=1.000, Egger test: p=0.891.





Supplementary Figure 7a.

F2 rs1799963 forest plot.
References




Supplementary Figure 7b.

F2 rs1799963 funnel plot.

Begg test: p=0.133, Egger test: p=0.017.




Supplementary Figure 7c.

F2 rs1799963: studies subdivided according to study size.



Supplementary Figure 8a.

FV rs6020 forest plot.

References



Supplementary Figure 8b.

FV rs6020 funnel plot.

Begg test: p=0.317.





Supplementary Figure 9a.

FV rs6025 forest plot.
References



Supplementary Figure 9b.

FV rs6025 funnel plot.

Begg test: p=0.456, Egger test: p=0.897.




Supplementary Figure 9c.

FV rs6025: studies subdivided according to study size.



Supplementary Figure 10a.

IL-10 rs1800896 forest plot.
References




Supplementary Figure 10b.

IL-10 rs1800896 funnel plot.

Begg test: p=0.621, Egger test: p=0.747.




Supplementary Figure 11a.

LPL rs1800590 forest plot.
References


Supplementary Figure 11b.

LPL rs1800590 funnel plot.

Begg test: p=0.602, Egger test: p=0.120.





Supplementary Figure 12a.

LPL rs268 forest plot.
References


Supplementary Figure 12b.

LPL rs268 funnel plot.

Begg test: p=1.000, Egger test: p=0.611.





Supplementary Figure 13a.

MTHFR rs1801133 forest plot.
References

***



Supplementary Figure 13b.

MTHFR rs1801133 funnel plot.

Begg test: p=0.531, Egger test: p=0.494.




Supplementary Figure 14a.

NOS3 27 bp-
VNTR in intron 4 forest plot.
References


Supplementary Figure 14b.

NOS3 27 bp-
VNTR in intron 4 funnel plot.

Begg test: p=0.071, Egger test: p=0.034.





Supplementary Figure 15a.

NOS3 rs2070744 forest plot.
References


Supplementary Figure 15b.

NOS3 rs2070744 funnel plot.

Begg test: p=0.484, Egger test: p=0.098.





Supplementary Figure 16a.

NOS3 rs1799983 forest plot.
References


Supplementary Figure 16b.


NOS3 rs1799983 funnel plot.

Begg test: p=0.960, Egger test: p=0.561.



Supplementary Figure 17a.

SERPINE1 rs1799889 forest plot.


References


Supplementary Figure 17b.

SERPINE1 rs1799889 funnel plot.

Begg test: p=0.102, Egger test: p=0.197.


Supplementary Figure 17c.

SERPINE1 rs1799889: studies subdivided according to study size.





  1   2   3   4   5   6   7


The database is protected by copyright ©hestories.info 2017
send message

    Main page